Rockefeller University Staff Scientist in New York, New York
Job Title Staff Scientist
Laboratory / Department Genetically Encoded Small Molecules
Researchers in the Laboratory of Genetically Encoded Small Molecules are working on projects related to the human microbiome, bacterial small molecules and host microbial interactions. The lab's research is focused on identifying bacterial genes, pathways and molecules that influence host-cellular functions and developing these host-microbial interactions into novel treatments for human disease. To this end we focus on three major areas of research: 1) high throughput screening of bacterial metabolites and genes to identify effector functions, 2) mouse models of inflammatory and metabolic diseases and 3) in vivo validation of bacterial metabolites and genes in human cohorts.
Working as part of a team that is further developing the lab's Synthetic-Bioinformatic Natural Product discovery platform, will focus on the total synthesis of novel bioactive small molecules. From its inception, the field of synthetic chemistry has drawn inspiration from bacterial small molecules (i.e., antibiotics, antifungals, anticancer agents, etc.). Unfortunately, metabolite discovery methods only access a small fraction of the molecules present in nature thereby limiting the diversity of natural structures that can serve as synthetic targets. The Laboratory recently outlined a new discovery platform that circumvents this bottleneck. In this approach, which they have termed Synthetic-Bioinformatic Natural Products, bioinformatic algorithms are used to predict chemical structures (i.e., synthetic targets) directly from bacterial genomic sequence data, and the predicted structures are then chemically synthesized and assayed for bioactivity. We are looking for a highly motivated, creative, collaborative and talented synthetic chemist to work on a multidisciplinary team that is expanding this new paradigm for using synthetic chemistry to discover novel biomedically relevant small molecules.
Ph.D. in chemistry or a related field required. Must have prior synthetic chemistry research experience. Must also demonstrate a strong track record of research productivity, scientiﬁc rigor, excellent communication skills, and an ability to work both independently and as part of a team. Experience with peptide synthesis, puriﬁcation, characterization, and bioassays a plus.
The Rockefeller University is an Equal Opportunity Employer - Minorities/Women/Disabled/Veterans