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Rockefeller University Research Assistant, Proteomics in New York, New York

Job: IRC23479


Job Title Research Assistant, Proteomics

Laboratory / Department Proteomics Resource Center

Department Description

The Proteomics Resource Center at The Rockefeller University masters most aspects of mass spectrometry based proteomics which includes, denovo sequencing, targeted studies, quantitative proteomics profiling based on label free quantitation as well as metabolic labelled samples (SILAC), chemical labeling, tandem-mass tag technology, absolute quantitation and global post translational analysis. The Center also offers LC-MS based analysis of small molecules, polar metabolites and lipids. Very importantly, the Center is a source for help with planning of mass spectrometry based experiments and has the capability to offer in-depth collaborative analysis. Also, the PRC is operated in a boutique style; encouraging the scientists of the Center to work closely with users to create a tailored approach to fit the many unique questions that can be answered by analytical mass spectrometry. The PRC is equipped with Orbitrap type mass spectrometers (high resolution/high mass accuracy), operates a triple quadrupole and can separate analytes using both nano and high flow liquid chromatography. The Center is equipped with multiple high performance servers for data analysis.In addition to analysis by mass spectrometry, the Center offers production of custom peptides and peptide libraries and different pre-mass spectrometry fractionation techniques, which include off-line separation of peptides and proteins by liquid chromatography.

Detailed Description

Reporting to the Director of the Proteomics Resource Center, The Research Support Assistant will be responsible for maintaining and operating nano-flow and high-flow LC-MS and related equipment, interacting with and advising investigators with regard to proteomics experiments, developing and implementing technologies in the Center, processing, analyzing, and interpreting data and reporting findings to investigators and the Director, generating standard operating procedures, tracking and submitting billing and purchasing information, and monitoring and maintaining laboratory appearance.

Job Requirements

Bachelor's degree in science required; educational emphasis in mass spectrometry, analytical chemistry or a related field preferred. Must have strong analytical and practical skills in protein sample preparation, LC-MS, and data analysis and interpretation. Excellent communication skills in oral and written English, ability to work independently as well as part of a team, and flexibility to interact with a diverse group of researchers required. In-depth experience with protein identification, quantitation, de novo sequencing, and characterization of post-translational modifications necessary. Hands-on experience with mass spectrometry, preferably Orbitrap type instruments, and in-depth knowledge of instrument operation and maintenance, data interpretation, and knowledge of background literature required. Practical experience with bioinformatics and "global proteomics" is desirable. Must have the ability to maintain and expand knowledge of mass spectrometry techniques through self-education, dialog with other experts, reading literature, and attending conferences and courses as necessary.

Additional Details

The Rockefeller University is an Equal Opportunity Employer - Minorities/Women/Disabled/Veterans